… We next examined whether selective activation of somatodendritic DREADDs impacts cocaine
potency at distal DATs in the NAc. We implanted bilateral cannulae targeted to the VTA of …

… Attenuating inhibitory effects of Tat and cocaine on DA transport are important for preventing
… directly targeting the specific binding sites on hDAT for Tat could provide a viable …

… levels such as the type achieved by allosteric targeting of dopamine transporter activity. …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …

… Dopamine transporter (DAT) is the target of cocaine and HIV-1 … effect of cocaine on DA
uptake and attenuate the effects of … to the extracellular region where it interacts directly with Tat …

… for cocaine is determined by other targets or mechanisms. Finally, we outline a novel approach
for relating drug–target … Cocaine-induced increases in extracellular dopamine levels, and …

… 2) reduced effects of cocaine on extracellular DA … attenuating subjective or reinforcing
effects of cocaine 59 , it is possible that phendimetrazine may be successful as part of a dual-target …

… -dependent monoamine transporter 23 , is a clinical target for … addictive effects of psychoactive
substances such as cocaine and … extracellular dopamine leading to attenuated dopamine-…

… block 1) extracellular-to-intracellular monoamine transport (ie… neurochemical effects and
that it attenuates cocaine effects … , a lack of plausible non-DAT targets, and a failure to observe …

… the extracellular and intraneuronal concentrations of dopamine… could be targeted to provide
new therapeutic approaches for … Lack of cocaine effect on dopamine clearance in the core …

… reinforcement, we serendipitously identified a novel therapeutic target… Extracellular dopamine
was recorded by applying a … indicating that phasic dopamine release is attenuated in LgA+…